CAS 1126-09-6

Ethyl isonipecotate,C8H15NO2,CAS 1126-09-6

1126-09-6

Properties

Synonyms Ethyl piperidine-4-carboxylate, H-DL-Inp-OEt
CAS Number 1126-09-6
Formula C8H15NO2
Formula Weight 157.21
Boiling Point 203-205°
Flash Point 80°(176°F)
Density 1.021
Refractive Index 1.46
Solubility Fully miscible with water
Purity 99%

Applications
It is used as a reactant for synthesis of SMN protein modulators, β-aryl and β-amino-substituted aliphatic esters by rhodium catalyzed tandem double bond migration/conjugate addition, nitroethylenediamines by nucleophilic ring opening of nitroimidazolidinone. It is also involved in the reactions of RhoA inhibitors for cardiovascular disease therapy and saccharin derived Mannich bases as antimicrobials and antioxidants. It is employed as a reactant for one-pot reductive amination and Suzuki-Miyaura cross coupling of formyl aryl and heteroaryl MIDA boronates.

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Notes
Store at room temperature. Incompatible with strong oxidizing agents.

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